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Our 7th annual international symposium will focus on advances in the field of Mechanobiology that have resulted in the development of new types of pharmaceuticals, drug delivery systems, engineered tissues, and wearable therapeutic devices that leverage physical forces or target mechanical signaling pathways as a core part of their mechanism of action. Organized by Wyss Institute Core Faculty members Dave Mooney and Don Ingber, the day will include a number of distinguished speakers who will provide examples of how mechanics is being harnessed in ways that can transform the future of medicine. 
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Tuesday, September 20
 

7:30am

Check-in
Refreshments will be available for registered attendees. Check-in is located at the Martin Conference Center (77 Avenue Louis Pasteur, Boston), near the Amphitheater.

Tuesday September 20, 2016 7:30am - 8:15am
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

8:15am

Welcome from the Institute
Speakers
avatar for Don Ingber

Don Ingber

Wyss Institute, Harvard University
Donald Ingber, M.D., Ph.D., is the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children's Hospital, and Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences. He received his B.A., M.A., M.Phil., M.D. and Ph.D. from Yale... Read More →


Tuesday September 20, 2016 8:15am - 8:30am
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

8:30am

Inhibitors of Mechanical Channels as Practical Therapeutic Targets in Mechanopathology
Speakers
avatar for Philip Gottlieb

Philip Gottlieb

Research Associate Professor, State University of New York at Buffalo
Dr. Philip Gottlieb received his Ph.D. from the organic chemistry department at the Weizmann Institute of Science, where he made peptide analogues to stimulate the phagocytosis of white blood cells.  He then worked as a postdoctoral fellow at the University of Colorado in Boulder, using nucleic acid analogues to study protein-DNA interactions. As a faculty member he continued and expanded the work to include RNA analogues and ribozymes. In... Read More →


Tuesday September 20, 2016 8:30am - 9:00am
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

9:00am

Forcing Form and Function
Speakers
avatar for Valerie M. Weaver

Valerie M. Weaver

Center for Bioengineering and Tissue Regeneration University of California, San Francisco
Dr. Valerie Weaver is currently the Director of the Center for Bioengineering and Tissue Regeneration in the Department of Surgery, and is a Professor in the Departments of Surgery, Anatomy and Bioengineering and Therapeutic Sciences at UCSF in San Francisco, CA. Her education took place in Canada, with a bachelor’s degree in Chemistry from the University of Waterloo, an Honors Bachelor’s and PhD degree in Biochemistry from the... Read More →


Tuesday September 20, 2016 9:00am - 9:30am
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

9:30am

Mechanically-activated therapeutics for cardiovascular and regenerative medicine
Speakers
avatar for Don Ingber (Session Chair)

Don Ingber (Session Chair)

Wyss Institute, Harvard University
Donald Ingber, M.D., Ph.D., is the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Judah Folkman Professor of Vascular Biologyat Harvard Medical School and the Vascular Biology Program at Boston Children's Hospital, and Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences. He received his B.A., M.A., M.Phil., M.D. and Ph.D. from Yale... Read More →


Tuesday September 20, 2016 9:30am - 10:00am
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

10:00am

Coffee Break
Coffee and refreshments will be available for registered symposium attendees.

Tuesday September 20, 2016 10:00am - 10:30am
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

10:30am

Micromechanical Forces in Wound Healing and Soft Tissue Regeneration
Speakers
avatar for Dennis P. Orgill

Dennis P. Orgill

Brigham and Women’s Hospital, Harvard Medical School
Dr. Orgill is Vice Chairman for Quality Improvement in the Department of Surgery at Brigham and Women's Hospital and Professor of Surgery at Harvard Medical School. He is a reconstructive plastic surgeon and has a PhD from MIT in Medical Engineering. He is the Director of the Brigham and Women's Hospital Wound Care Center and runs a tissue engineering and wound healing Laboratory. His lab at BWH is working to develop better technologies to... Read More →


Tuesday September 20, 2016 10:30am - 11:00am
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

11:00am

Connective Tissue, Stretching, Wound Healing and Cancer
Speakers
avatar for Helene Langevin

Helene Langevin

Bernard Osher Professor in Residence of Complementary and Integrative Medical Therapies, Harvard Medical School, Brigham and Women's Hospital, University of Vermont College of Medicine
Helene Langevin received an MD degree from McGill University in 1978. She did a post doctoral research fellowship in Neurochemistry at the MRC Neurochemical Pharmacology Unit in Cambridge, England, residency in Internal Medicine and fellowship in Endocrinology and Metabolism at Johns Hopkins Hospital. She is a Professor in Residence of Medicine and Director of the Osher Center for Integrative Medicine at Harvard Medical School and Brigham and... Read More →


Tuesday September 20, 2016 11:00am - 11:30am
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

11:30am

How Mechanobiology Guides Regeneration
Speakers
avatar for Georg Duda (Session Chair)

Georg Duda (Session Chair)

Founding Director, Julius Wolff Institut Charité – Universitätsmedizin Berlin
Prof. Dr.-Ing. Georg N. Duda is the founding director of the Julius Wolff Institute at the Charité, Humboldt University and Free University of Berlin. The Julius Wolff Institute brings together researchers from engineering, mathematics, biology, biochemistry and clinical scientists in order to develop new therapeutic strategies for regeneration of injured or degenerated joint, bones and muscles. Conceptually, Georg’s research aims at... Read More →


Tuesday September 20, 2016 11:30am - 12:00pm
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

12:00pm

Lunch
Tote lunches will be available for all registered symposium attendees.

Tuesday September 20, 2016 12:00pm - 1:30pm
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

1:30pm

Engineering Human Heart Muscle for Drug Screening and Modeling of Disease
Speakers
avatar for Gordana Vunjak-Novakovic

Gordana Vunjak-Novakovic

Laboratory for Stem Cells and Tissue Engineering, Columbia University
Gordana Vunjak-Novakovic is the Mikati Foundation Professor of Biomedical Engineering and a Professor of Medical Sciences at Columbia University, where she directs the Laboratory for Stem Cells and Tissue Engineering. The focus of her research is on engineering human tissues for regenerative medicine, stem cell research and modeling disease. She is well published and highly cited (>18,000 citations and h=82 on the ISI Web of Science... Read More →


Tuesday September 20, 2016 1:30pm - 2:00pm
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

2:00pm

Low Level Mechanical Signals as Anabolic Stimuli to Bone and Muscle: Developing a Non-Drug Intervention for Musculoskeletal Injury and Disease
Speakers
avatar for Clinton T. Rubin

Clinton T. Rubin

Stony Brook University
Clinton T. Rubin, Ph.D., is a SUNY Distinguished Professor and founding Chair of the Department of Biomedical Engineering at the State University of New York, in Stony Brook, New York.  He also serves as the Director of the Center for Advanced Technology in Medical Biotechnology, funded by the New York State foundation for Science, Technology and Academic Research (NYSTAR), which links the intellectual and physical resources of NY... Read More →


Tuesday September 20, 2016 2:00pm - 2:30pm
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

2:30pm

Biomaterial Mechanics and Musculoskeletal Regeneration
Speakers
avatar for David J. Mooney (Session Chair)

David J. Mooney (Session Chair)

Wyss Institute, Harvard John A. Paulson School of Engineering & Applied Sciences
David J. Mooney is studying the mechanisms that enable cells to receive and react to chemical and mechanical signals, such as cell adhesion molecules and cyclic strains. These signals carry information that instruct cells to alter their behavior by changing their level of proliferation or area of specialization. Sometimes the message being sent is to promote tissue growth: sometimes it's to attack diseased cells. Dave is working to develop... Read More →


Tuesday September 20, 2016 2:30pm - 3:00pm
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

3:00pm

Coffee Break
Coffee and refreshments will be available for registered symposium attendees.

Tuesday September 20, 2016 3:00pm - 3:30pm
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

3:30pm

Biological Restoration and Regeneration with Soft Wearable Robots
Session Chair
avatar for Conor Walsh (Session Chair)

Conor Walsh (Session Chair)

Wyss Institute, Harvard John A. Paulson School of Engineering & Applied Sciences
Conor Walsh is the John L. Loeb Associate Professor of Engineering and Applied Sciences at the Harvard John A. Paulson School of Engineering and Applied Sciences and a Core Faculty Member at the Wyss Institute for Biologically Inspired Engineering. He is the founder of the Harvard Biodesign Lab, which brings together researchers from the engineering, industrial design, apparel, clinical and business communities to develop new disruptive robotic... Read More →

Tuesday September 20, 2016 3:30pm - 4:00pm
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

4:00pm

Implantable devices with self-remodeling capacity
Speakers
avatar for Simon P. Hoerstrup

Simon P. Hoerstrup

Chair and Director, Co-Director, Institute for Regenerative Medicine, University of Zurich, ETH, Wyss Zurich, Wyss Institute at Harvard University
Simon P. Hoerstrup, MD, PhD, is a physician and leader in the field tissue engineering and regenerative medicine. He is Chair and Director of the Institute for Regenerative Medicine and Co-Director of the recently founded Wyss Translational Center Zurich in Switzerland. Hoerstrup is also Professor of Biomedical Engineering at the Technical University Eindhoven in the Netherlands, Associate Member of the Department of Health Science Technology... Read More →


Tuesday September 20, 2016 4:00pm - 4:30pm
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

4:30pm

Preventing Infant Apnea Using the Laws of Mechanics
Speakers
avatar for David Paydarfar

David Paydarfar

Wyss Institute, University of Massachusetts Medical School
David Paydarfar is an Associate Faculty Member at the Wyss Institute for Biologically Inspired Engineering at Harvard University, and Professor and Executive Vice Chair of Neurology at the University of Massachusetts Medical School.  He studies oscillatory neural systems at the cellular, tissue and organismal levels, focusing on circuits involved in breathing, swallowing, and other autonomic functions. He seeks to understand... Read More →


Tuesday September 20, 2016 4:30pm - 5:00pm
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

5:00pm

Synthesis and Close
Speakers
avatar for Don Ingber

Don Ingber

Wyss Institute, Harvard University
Donald Ingber, M.D., Ph.D., is the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children's Hospital, and Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences. He received his B.A., M.A., M.Phil., M.D. and Ph.D. from Yale... Read More →


Tuesday September 20, 2016 5:00pm - 5:15pm
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115

5:15pm

Reception
Tuesday September 20, 2016 5:15pm - 6:00pm
Joseph B. Martin Conference Center 77 Avenue Louis Pasteur, Boston, Ma 02115